Mosquito decay reflects the diversity of chemical and olfactory structures

Similar Odorants Elicit Different Behavioral and ...- Mosquito decay reflects the diversity of chemical and olfactory structures ,May 25, 2011·An intriguing question in the field of olfaction is how animals distinguish among structurally similar odorants. We systematically analyzed olfactory responses elicited by a panel of 25 pyrazines. We found that structurally similar pyrazines elicit a wide range of behavioral responses from Drosophila larvae. Each pyrazine was tested against all functional receptors of the larval Odor …Adaptation of olfactory receptor abundances for efficient ...Feb 26, 2019·Olfactory receptor usage is highly heterogeneous, with some receptor types being orders of magnitude more abundant than others. We propose an explanation for this striking fact: the receptor distribution is tuned to maximally represent information about the olfactory environment in a regime of efficient coding that is sensitive to the global context of correlated sensor responses.



Cellular Basis for Response Diversity in the Olfactory ...

An emerging idea in olfaction is that temporal coding of odor specificity can be intrinsic to the primary olfactory receptor neurons (ORNs). As a first step towards understanding whether lobster ORNs are capable of generating odor-specific temporal activity and what mechanisms underlie any such heterogeneity in discharge pattern, we characterized different patterns of activity in lobster ORNs ...

(PDF) Multiple activities of insect repellents on odorant ...

Multiple activities of insect repellents on odorant receptors in mosquitoes. Medical and Veterinary Entomology, 2011. Joseph Dickens

Cellular basis for response diversity in the olfactory ...

Apr 13, 2012·Introduction. Attention has long focused on the role of the first olfactory relay, e.g., the arthropod antennal/olfactory lobe and the mammalian olfactory bulb, in generating the spatiotemporal code by which odors are recognized and discriminated (e.g., , , , , ).However, recent findings indicate that, at least in insects, the primary ORNs themselves are capable of generating temporal activity ...

Evolving olfactory systems on the fly: Trends in Genetics

The detection of odour stimuli in the environment is universally important for primal behaviours such as feeding, mating, kin interactions and escape responses. Given the ubiquity of many airborne chemical signals and the similar organisation of animal olfactory circuits, a fundamental question in our understanding of the sense of smell is how species-specific behavioural responses to odorants ...

Global Features of Neural Activity in the Olfactory System ...

Jul 07, 2010·Odor identity is coded in spatiotemporal patterns of neural activity in the olfactory bulb. Here we asked whether meaningful olfactory information could also be read from the global olfactory neural population response. We applied standard statistical methods of dimensionality-reduction to neural activity from 12 previously published studies using seven different species.

Functional Characterization of Insect Olfactory Receptor ...

Mar 19, 2013·The main olfactory organ of insects is a pair of external appendages, the antennae. Insect antennae bear minute cuticular structures, the sensilla, which house the olfactory receptor neurons (ORNs, also designated as olfactory sensory neurons or OSNs).

1 Mosquito indolergic receptors belong to an ancient and ...

Aug 04, 2020·35 conditions. Chemical cues are amongst the most predominant ecological drivers of animal behavior 36 and exert major influences on resource acquisition [1, 2]. Perhaps nowhere in animal lineages is this 37 dependency on olfactory information more evident than in …

Odorant reception in the malaria mosquito Anopheles ...

The mosquito Anopheles gambiae is the major vector of malaria in sub-Saharan Africa. It locates its human hosts primarily through olfaction, but little is known about the molecular basis of this ...

Peripheral olfactory signaling in insects - Europe PMC ...

Olfactory signaling is a crucial component in the life history of insects. The development of precise and parallel mechanisms to analyze the tremendous amount of chemical information from the environment and other sources has been essential to their evolutionary success.

Sex- and tissue-specific transcriptome analyses and ...

Nov 06, 2019·The sophisticated insect olfactory system plays an important role in recognizing external odors and enabling insects to adapt to environment. Foraging, host seeking, mating, ovipositing and other forms of chemical communication are based on olfaction, which requires the participation of multiple olfactory genes. The exclusive evolutionary trend of the olfactory system in Orthoptera insects is ...

Sensilla of haematophagous insects sensitive to vertebrate ...

When the sensory complements of the various groups of blood-feeders are compared, three points emerge. First, reduction in numbers of olfactory chemosensilla that mediate odour cues used in long-distance, host-orientation occurs in male nematocerans and in females of completely autogenous species of mosquitoes and black flies.

Expression and evolutionary divergence of the non ...

The diversity of expression patterns may be important for determining species-specific olfactory profiles, such as in the detection of fruit odours by fruit flies and human host odours by mosquitoes [50, 53]. The patterns in fig wasps may reflect species-specific adaptations to …

How Mosquitoes Detect People | National Institutes of ...

To identify more suitable compounds, the team developed a computer simulation method to screen almost half a million chemical compounds in search of structures that might interact with the receptor. They identified 138 compounds that were pleasant smelling, …

Robust olfactory responses in the absence of odorant ...

Oct 25, 2019·Animals depend critically on olfactory systems to interpret the quality, quantity, and temporal structure of chemical cues in their environments. The molecules, neurons, and circuits underlying olfaction are subjects of intense investigation in many animals, including the fruit fly Drosophila (Leal, 2013; Su et al., 2009; Wilson, 2013).

Odourant reception in the malaria mosquito Anopheles ...

Mosquitoes transmit many diseases, including malaria, which afflicts hundreds of millions of people each year 1.The malaria burden is heaviest in sub-Saharan Africa, where the An. gambiae mosquito is the major vector.An. gambiae relies heavily on olfactory cues to identify its human hosts 2 – 4, but the molecular basis of host-seeking behavior is unknown.

Cellular basis for response diversity in the olfactory ...

Apr 13, 2012·Introduction. Attention has long focused on the role of the first olfactory relay, e.g., the arthropod antennal/olfactory lobe and the mammalian olfactory bulb, in generating the spatiotemporal code by which odors are recognized and discriminated (e.g., , , , , ).However, recent findings indicate that, at least in insects, the primary ORNs themselves are capable of generating temporal activity ...

The molecular and cellular basis of olfactory-driven ...

Apr 29, 2008·The mosquito Anopheles gambiae is the principal Afrotropical vector for human malaria. A central component of its vectorial capacity is the ability to maintain sufficient populations of adults. During both adult and preadult (larval) stages, the mosquitoes depend on the ability to recognize and respond to chemical cues that mediate feeding and survival.

Structure–activity relationships on the odor detectability ...

Olfactory studies indicate that the detection of odorants by olfactory receptors (ORs) is performed in a combinatorial fashion, such that each receptor can bind different odorants and, conversely, each odorant is capable of binding to various receptors (Malnic et al. 1999).Under such an arrangement, knowledge of how an odorant interacts with one or a few ORs, e.g., Abaffy et al. (), Repicky ...

Functional integration of “undead” neurons in the ...

Programmed cell death (PCD) is widespread during neurodevelopment, eliminating the surpluses of neuronal production. Using the Drosophila olfactory system, we examined the potential of cells fated to die to contribute to circuit evolution. Inhibition of PCD is sufficient to generate new cells that express neural markers and exhibit odor-evoked activity. These “undead” neurons express a ...

Evidence for inhibition of cholinesterases in insect and ...

Aug 05, 2009·N,N-Diethyl-3-methylbenzamide (deet) remains the gold standard for insect repellents. About 200 million people use it every year and over 8 billion doses have been applied over the past 50 years. Despite the widespread and increased interest in the use of deet in public health programmes, controversies remain concerning both the identification of its target sites at the olfactory system and ...

Visual-Olfactory Integration in the Human Disease Vector ...

], and how the combination of olfactory and visual information is integrated in the mosquito brain remains unknown. In the present study, we used a tethered-flight light-emitting diode (LED) arena, which allowed for quantitative control over the stimuli, and a control theoretic model to show that CO 2 modulates mosquito steering responses toward vertical bars.

Manipulating synthetic optogenetic odors reveals the ...

Jun 19, 2020·Any olfactory input is transformed to temporal activations in discrete spatial channels (spots or, more generally, glomeruli). Activations decay over time and are represented by exponential waveforms. The decay slope reflects animals’ sensitivity to temporal perturbations, with slower decays corresponding to higher invariance to temporal shifts.

The human olfactory transcriptome | BMC Genomics | Full Text

Aug 11, 2016·Olfaction, the sense of smell, is a versatile and sensitive mechanism for detecting and discriminating thousands of volatile odorants. Olfactory recognition is mediated by a large repertoire of olfactory receptors (ORs), which activate a G-protein-mediated transduction cascade [1–4].The ORs are expressed on the ciliated dendrites of olfactory sensory neurons located in the olfactory epithelium.

Conservation of Indole Responsive Odorant Receptors in ...

At a molecular level, mosquito olfactory signal transduction begins on the surface of ORN dendrites that lie within antennal, labellar, and maxillary palp sensilla. Although the precise mechanisms underlying this process are still emerging ( Sato et al. 2008 ; Wicher et al. 2008 ), it is clear that odorant receptors (ORs) play a significant, if ...